This school is named in memory of one of the five sisters (nuns) murdered during the infamous “Operation Octopus” of October 1992. Sister Kathleen McGuire belonged to the Adorers of Precious Blood Congregation. She was Mid-Western, Irish-American from a small community called Pond, in Eastern Illinois.  She worked for a number of religious organizations before coming to Liberia in 1991 after being convinced by her friend and mentor Sister Shirley Kolmer convinced her to. Before her death, she managed the affair of both St. Michael Catholic School in Gardnesville and St. Patrick High School on Capital By-pass, Monrovia.

Archbishop Michael K. Francis had earlier bought a piece of Land located in Cooper Farm in 1984 from one Mr. Jenkins Cooper, so in 1995, he decided to build a school in memory of Sr. Kathleen McGuire. The Construction of a six-classroom building with a principal’s office along with a storeroom and flush toilets for staff and students started on February 8, 1995. It was turned over to the Catholic Education Secretariat on June 20, of the same year to educate every child that enters the walls of the school.

Registration started and the first day of school was June 24, 1995, behind the scheduled date of June 12 of the year due to the ill health of the coordinator who later died in Ghana.